Published Research Articles

Below you will find a list of published articles featuring the research here at St. Anthony’s Research & Education Institute.

The Effect of Increased Fiber Ingestion on Lipid Levels and Body Mass: A 4-Week Trial

Hyperlipidemia and hypercholesterolemia are major risk factors for the development of atherosclerosis, coronary artery disease and myocardial infarction. Several studies have suggested that increases in dietary fiber such as those found in plant products may have a positive impact on weight and cholesterol levels-especially when the participant is highly motivated to make personal lifestyle improvements. The current Phase ‘0’, pilot study, was conducted to assess these effects on a cohort of moderately obese individuals using a proprietary blend of sugar beet pulp, apple pectin, and oat sterols.

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Improved Creatine Stability and pH Profile for Kre-Alkalyn

Creatine modification for commercialization has included many variations to increase its stability. The current report assesses the stability of a sodium bicarbonate buffered creatine sold under the brand name Kre-Alkalyn under various conditions. Kre-Alkalyn is shown to have a good 6 year stability and shelf life under accelerated testing. It maintains a high pH over time compared to normal creatine and can be augmented with additional stabilizing buffers. This stability and buffering profile may serve useful in providing continued creatine availability.

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Rodent and Human Trials of the Testosterone Modulating Experimental Nutraceutical Taxadrol

Testosterone therapy is commonly used by individuals dealing with testosterone deficiency (TD). TD affects older men and athletes with a history of anabolic steroid use. In this study a novel nutraceutical product, Taxadrol, was tested in rodents and human subjects to assess toxicity and activity as a testosterone therapy.

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A Single-Center, Double-Blind Placebo Controlled Study to Evaluate the Efficacy of Kre-Celazine®, an Oral Buffered Creatine Cetylated Fatty Acid Compound, in its Ability to Reduce Site-specific Inflammation and  Pain

In order to determine whether an oral, alkali bufferedcreatine – cetylated fatty acid compound was capable of reducing site-specific chronic joint and muscle related inflammation/pain with equal effectiveness, 35 subjects, each fulfilling the entrance criteria, were divided into 2 groups – Group A (“Test Compound” group) and Group B (“Placebo group”). Each participant took the same number of capsules irrespective of their group assignment, for 30 consecutive days. Efficacy was based on the final evaluation of pre and post blood tests, physical examinations (entrance and exit) and participants’ “Pain Journal” comments.

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Kre-Celazine as a Viable Treatment for Juvenile Rheumatoid Arthritis/Juvenile Idiopathic Arthritis — A Pilot Study

The purpose of this study was to ascertain whether an oral, non-prescription, nutritional supplement compound composed of a proprietary alkali-buffered creatine monohydrate and cetylated fatty acids mixture (Kre-Celazine) was efficacious in reducing or eliminating refractory pain and inflammation, without untoward effects, in Juvenile Rheumatoid Arthritis ( JRA), which is also called Juvenile Idiopathic Arthritis (JIA). JRA/JIA is a patho-physiologically complex, chronic childhood autoimmune inflammatory disease of unknown etiology.

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The Effect of an Alkaline Buffered Creatine (Kre-Alkalyn®), on Cell Membrane Behavior, Protein Synthesis, and Cisplatin-mediated Cellular Toxicity

Endogenous creatine is created in a stable, slightly alkaline, environment. It is reasonably efficacious in delivering ATP to its target in the body. Manufactured creatine is introduced orally into an acidic environment. A percentage is degraded in the stomach, or as a result of acidophilic bacterial exposure. In either case, a certain amount of orally ingested creatine never becomes available for ATP transport. Creatine supplementation, in and of itself, has been shown to influence endothelial permeability and cell surface reactivity to a modest degree, potentially interfering/blocking an inflammatory stimulus.

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Efficacy and Examination of an Alkaline Buffered Commercial Creatine Supplement- Kre-Alkalyn®, in Athletes

Creatine is used by the human body to perform muscular acts. It has therefore been established as a supplement for bodybuilders and other athletes. In addition, modifications to creatine have been made in commercial laboratories for the purpose of increasing the efficacy of this supplement. Here, we examine the commercially available buffered creatine, Kre-Alkalyn®, in several athletic populations including members of the Bulgarian Olympic weightlifting team. Several factors, including qualitative questionnaires and physiological tests, were performed to determine the efficacy of Kre-Alkalyn® when compared to placebo or traditional creatine monohydrate.

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Buffered vs. Non-Buffered Aliphatic Fatty Acids and their Anti-Proliferative Effects in Human Tumor Cell Lines

Tumor cells generate a micro-acidic environment due to increased fermentative metabolism and poor perfusion. It is believed that this action is responsible for creating a lower pH environment which promotes invasive tumor growth in primary and metastatic cancers, through a form of acid-induced micro-environmental remodeling. Dietary fats, both saturated and unsaturated, have profound impacts on the viability and growth of neoplastic cells. This study examines the impact that saturated and unsaturated fatty acids, both alkalized and nonalkalized, have on the viability and growth of various neoplastic cell lines.

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A Designer Sugar, Karbolyn®, Leads to Tighter Sugar Control than Glucose in a Pre-Diabetic Cohort

KarboLyn®, a designer sugar for elite athletes, provides a rapidly metabolized
carbohydrate to the muscle, without the ‘crash’. Recent investigations have suggested that KarboLyn® may be differentially processed by those with impaired glucose control. Therefore, the aim of the study was to determine whether KarboLyn® can promote a more controlled glucose utilization pattern for individuals with insulin resistance.

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